Rosa damascena dry extract

Short summary description:

• Categories/Mainstream: Dry plant extracts
• Botanical Source: Rosa damascena Mill.
• Country of origin: Bulgaria

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The origin of raw material

Rosa damascena is a primary livelihood for the local population residing in central Bulgaria, specifically in the "Valley of Roses." It is a perennial plant that blooms during May and June. It is primarily used to produce aromatic products such as essential oil, floral water, concrete, and absolute. Its unorthodox processing into a dry extract and its transformation into an interesting substitute for Ginkgo biloba will be presented in the text below.

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Technological process

Fresh raw material is subjected to extraction using a water-alcohol solution, and a percolation process is carried out. The resulting liquid extract is concentrated and filtered twice. It is then subjected to a spray-drying process. The batch of the product is milled and homogenized. The final product is placed in a double polyethylene bag suitable for food contact and in a fibber barrel.

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Certification and characterisation:

• Produced according to ISO 9001:2015 and GMP of cosmetic regulations.
• Produced according to FSSC 22000 – food ingredient.

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Properties

Research on our product Rose Damascena dry extract

The dry extract of Rosa damascena Mill demonstrates significant potential for application in cosmetics and medicine due to its antioxidant, antimicrobial, and cytoprotective properties. The phenolic-enriched fraction (EAE) shows strong antioxidant activity, surpassing standard antioxidants such as butylated hydroxytoluene (BHT), owing to its high content of phenolic compounds and flavonoids. The antimicrobial activity of the extracts is clearly pronounced against bacteria like Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis, making them suitable for products targeting skin infections and acne. However, there is no observed activity against the fungus Candida albicans, limiting their use in antifungal applications.

 

Toxicity tests reveal that the extracts have low cytotoxicity toward normal human skin fibroblasts, making them safe for skin application. Although a short-term decrease in cell viability is observed in the first 24 hours, the cells fully recover after 72 hours. In human hepatocellular carcinoma (HepG2) cells, the extracts exhibit dose-dependent toxicity at higher concentrations, indicating the need for careful dosing in medical applications.

 

In conclusion, the dry extract of Rosa damascena Mill holds great potential as a natural antioxidant and antimicrobial agent in cosmetic and medical products, especially those aimed at caring for problem skin prone to acne.

 

Reference: N., Topouzova-Hristova, T., Veleva, R., Moskova-Doumanova, V., Dimitrov, V., & Simova, S. (2023). Phytochemical profile, antioxidant potential, antimicrobial activity, and cytotoxicity of dry extract from Rosa damascena Mill. Molecules, 28(22), 7666. https://doi.org/10.3390/molecules28227666

 

Supporting of cognitive function

Rosa damascena extract can be effectively incorporated into various products to enhance health and well-being. It can serve as a key ingredient in dietary supplements, providing antioxidant benefits that support cognitive function. In the food industry, the extract is ideal for herbal teas and healthy snacks, promoting mental clarity while adding a unique flavor. Additionally, its antioxidant properties make it a valuable component in cosmetics, particularly in anti-aging creams and lotions, where it hydrates and protects sensitive skin. Furthermore, Rosa damascena can be added to natural juices or energy drinks to boost energy and concentration. Its use in aromatherapy products, such as essential oils, can promote relaxation and improve mood. Overall, Rosa damascena extract presents diverse applications across dietary, cosmetic, and wellness products, appealing to consumers seeking natural and beneficial solutions.

 

The impact of Rosa damascena extract on learning and memory using the Morris water maze and passive avoidance tests in rats subjected to a high-fat diet (HFD). The results from the Morris water maze test indicate no significant differences in escape latency, distance traveled, or swimming speed among the groups, suggesting that HFD and R. damascena have no influence on spatial memory.

 

However, HFD leads to cognitive impairment, as evidenced by decreased step-through latency in the passive avoidance test. This implies that HFD negatively affects learning and memory, increasing serum cholesterol and LDL levels while having no effect on triglycerides or HDL.

 

The administration of R. damascena extract shows a positive effect on memory in rats on an HFD, likely due to the antioxidant properties of the extract. However, R. damascena does not impact spatial memory, which may be attributed to differences in signaling mechanisms and neuronal circuits involved in each task.

 

In conclusion, the study demonstrates that R. damascena extract can prevent cognitive impairment induced by HFD but has no effect on spatial memory. These findings underscore the importance of antioxidants in preventing cognitive disorders arising from adverse dietary habits.

 

Reference: Rezvani-Kamran, A., Salehi, I., Shahidi, S., Zarei, M., Moradkhani, S., & Komaki, A. (2017). Effects of the hydroalcoholic extract of Rosa damascena on learning and memory in male rats consuming a high-fat diet. Pharmaceutical Biology, 55(1), 2065-2073. https://doi.org/10.1080/13880209.2017.1362010

Limiting the negative effect of obesity

Non-alcoholic fatty liver disease (NAFLD) is the term for a range of conditions caused by a build-up of fat in the liver. It's usually seen in people who are overweight or obese. Early-stage NAFLD does not usually cause any harm, but it can lead to serious liver damage, including cirrhosis, if it gets worse. Having high levels of fat in your liver is also associated with an increased risk of serious health problems, such as diabetes, high blood pressure and kidney disease.

 

The extract from Rosa damascena offers promising applications for the management of non-alcoholic fatty liver disease (NAFLD), which is one of the leading causes of chronic liver diseases, particularly in the context of the growing obesity epidemic. NAFLD is strongly associated with metabolic syndrome, diabetes, hypertension, and hypertriglyceridemia, and is known to be triggered by unhealthy dietary habits and high-calorie diets. While conventional drugs for NAFLD have various side effects, herbal remedies with lipid-lowering, antioxidant, and anti-inflammatory properties can play an important role in managing the disease.

 

R. damascena has traditionally been used to treat various ailments, including gastrointestinal issues. The current study confirmed the efficacy of the hydroalcoholic extract of Rosa damascena (RHE) in an animal model of NAFLD induced by a high-calorie diet. As a result of treatment with RHE, plasma lipid levels were significantly moderated in rats subjected to a high-calorie diet, and the extract demonstrated the ability to suppress liver enzymes AST and ALT.

 

Oxidative stress is a key risk factor in the development of NAFLD. Studies have shown that oxidative stress leads to increased expression of pro-inflammatory cytokines and depletion of hepatic antioxidant levels. The extract of R. damascena contains high levels of phenolic compounds known for their antioxidant properties, which have beneficial effects in various pathologies, including liver injuries.

 

Research has confirmed that phenolic compounds such as gallic acid, quercetin, and syringic acid present in RHE exhibit anti-inflammatory activity and inhibit inflammatory signaling pathways. For example, gallic acid has shown its ability to reduce oxidative stress and improve liver function, while quercetin reduces liver fat accumulation and improves metabolic parameters associated with metabolic syndrome.

 

In conclusion, the extract from Rosa damascena demonstrates positive effects as a dietary supplement and alternative treatment in the management of NAFLD. It significantly reduces elevations in serum triglycerides, cholesterol, and liver enzymes. Due to its safety and traditional use, R. damascena may be considered a candidate for adjuvant therapy in combination with conventional pharmacological treatments in future human studies involving patients with NAFLD.

 

Reference: Davoodi, I., Rahimi, R., Abdollahi, M., Farzaei, F., Farzaei, M. H., Memariani, Z., & Najafi, F. (2017). Promising effect of Rosa damascena extract on high-fat diet-induced nonalcoholic fatty liver. Journal of Traditional and Complementary Medicine, 7(2), 156-161. https://doi.org/10.1016/j.jtcme.2017.01.008

 

Limitation of painful menstruation

Rosa damascena extract on primary dysmenorrhea and compares its efficacy to mefenamic acid. Both treatments significantly reduced pain intensity in participants, highlighting the extract's potential as an effective analgesic for menstrual discomfort. Results showed no substantial difference in pain relief between the two groups, indicating that Rosa damascena may provide similar benefits to conventional medication. The analgesic properties of Rosa damascena are attributed to its bioactive compounds, such as flavonoids, which have demonstrated pain-relieving effects in various studies. Previous research has revealed the extract's ability to alleviate pain in animal models and during surgical procedures, further supporting its therapeutic potential. Given its effectiveness and traditional use, Rosa damascena extract presents a promising alternative for women seeking relief from menstrual pain. Future research should explore its long-term effects and optimal dosing to fully understand its benefits for managing dysmenorrhea. Overall, Rosa damascena stands out as a safe and natural option for addressing menstrual pain.

 

Reference: Bani, S., Hasanpour, S., Mousavi, Z., Mostafa Garehbaghi, P., & Gojazadeh, M. (2014). The effect of Rosa damascena extract on primary dysmenorrhea: A double-blind cross-over clinical trial. Iran Red Crescent Medical Journal, 16(1), e14643. https://doi.org/10.5812/ircmj.14643